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N Engl J Med (2017) 376(18):174861

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Interestingly, promoting GSH synthesis with NAC treatment, which can affect early (NAPQI scavenging) and later events (scavenging of mitochondrial peroxynitrite) [32], attenuated necrotic cell death but did not induce secondary apoptosis [58]

Therefore, the dosages used in clinical settings may differ from oral supplements

In conclusion, the present results indicate that cells transformed by chronic exposure to 3MC exhibited abnormal changes in the transsulfuration pathway, accompanied by increased availability of cysteine to taurine rather than GSH synthesis