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When it binds to IGF-1 receptors, it activates pathways inside the body that stimulate protein building, cell repair, and energy use

Under metabolic homeostasis, astrocytes play a pivotal role in Gln synthesis via an astrocyte-specific enzyme, the GS 24

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Current therapeutic approaches aim to modulate these pathways, including direct Nrf2 activation and glial-targeted interventions, although significant challenges persist in delivering antioxidant agents across the BBB and in validating neuroprotection markers