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The role of microglia in response to nicotine is further consolidated by experiments that show that microglial depletion reversed the microglial- related Nox2 and associated aberrant ROS production and also decreased anxiety-like behavior that is typical response to nicotine withdrawal (156)

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Long Term Effects Scientific literature and long term population studies consistently support that snus is a dramatically lower risk nicotine product, especially compared to cigarettes or other combustibles