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Mechanistically, coculture systems have demonstrated in EVCs and macrophages stimulated by CCL5/CCR1/CCR5 that axis-mediated BC cell growth and migration were independent of one another

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doi: 10.1016/j.pmedr.2016.06.002 43 MarghamJMcAdamKForsterMLiuCWrightCMarinerDet al

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Despite these advances, a substantial proportion of patients with melanoma show little response to ICIs, and relapses remain common among those who initially respond ( 3.7 CD47 Cluster of differentiation 47 (CD47) is an immune checkpoint molecule commonly referred to as the dont eat me signal and has attracted substantial attention due to its role in facilitating tumor immune evasion