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Therapeutic Research Protocol Dose: 5.0 10.0 mg (= 100200 clicks) Duration: 3 consecutive days per cycle Frequency: 1 cycle every 3 4 weeks Cycle Interval: 3 4 weeks off before repeating Goal / Description: Higher-dose pulse evaluated for accelerated senescent cell clearance in research models

16, 19 To suppress the activity of circulating TGF , TGF -neutralizing antibodies (R&D Systems, Minneapolis, MN) were administered via a single intraperitoneal injection at 1 mg/kg 2 h before AOM injection

Expected Timeline: When Will You See Results

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