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More recently, the term endocannabinoidome has been coined to describe this group of endocannabinoids, receptors, and biosynthetic and degradation enzymes ( 3 The regulation of cytochrome P450 metabolic activity 3.1 Induction and inhibition Cytochrome P450 (P450) family comprise 18 families and over 50 isoenzymes (Nebert et al., 2013)