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Data on potential long-term harms of e-cigarette use are not available, and both the task force and patients rated harms as important outcomes for decision-making.23 , 72 Evidence from trials showed high levels of continued use of e-cigarettes following their use for smoking cessation.73 A recent analysis of 9 e-cigarette studies found that among people who successfully quit combustible tobacco using e-cigarettes, 70% continued using e-cigarettes at 6 months or longer.74 For those who continue to use e-cigarettes long term after quitting smoking, there is uncertainty about the health effects

The action of nicotine in the brain can also trigger physiological effects outside the brain

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