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Because GPX4 can be expressed in antitumor immune cells (such as T cells [28], dendritic cells [169], and neutrophils [170]) and immunosuppressive cells (e.g., T reg [171]), nonselective targeting of GPX4 may cause immune side effects during preclinical cancer therapy

But whether it's actually ruined depends on two factors most guides gloss over: whether the peptide was reconstituted and how long it remained above refrigeration temperature

In 2016, Jung et al