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1), we have a methodological framework for further studies to understand how pH and the protonated versus unprotonated nicotine contribute to nicotine pulmonary toxicity, absorption/rate of transfer in the lungs, and the bioavailability

In this context, Spain currently enforces Royal Decree 579/2017 of June 9, which regulates certain aspects of the manufacturing, presentation, and marketing of tobacco and related products in accordance with Directive 2014/40/EU of April 3

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