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Rival companies noticed the popularity of menthol cigarettes like Kools in the African-American market niche, and began vying for brand loyalty and profit

FIGURE 3 In the HCS assessment (Table 1), Normal Human Bronchial Epithelial (NHBE) cells were exposed in a concentration-dependent manner to 34 individual flavor ingredients and to non-flavored (base) matrix for either 4 h or 24 h (30 min for the NF-kB translocation endpoint.) (Figure 4 in three heatmaps which grouped these flavor ingredients based on minimal effective concentration (MEC) profile similarities and the Tox or Phenotypic Score (ratio of MEC base solution/MEC flavored solution) is shown in Table 2

This monograph emphasizes the complexity and multidimensionality of nicotine dependence and its maturation from initial experimentation to addiction

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To this, mellow Burleys and Golden Virginias are added for mildness and depth of flavor