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"And its possible that [smoking's] effect on ACE2 levels isnt the most important factor." Smoking linked to severe infection Mounting evidence suggests that, compared with nonsmokers, people who smoke cigarettes face a higher risk of developing severe complications and dying from COVID-19 infections

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Similarly for DALYs incurred by tobacco use, 14.73% are due to cancer (0.72% of all DALYs incurred), but tobacco also makes large contributions to those many other conditions