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Numbing cream and optional cooling therapy minimize pain

Despite advances in chemotherapy, radiotherapy, and targeted therapies, challenges such as poor drug accumulation, systemic toxicity, and multidrug resistance persist, partly due to elevated intracellular GSH levels that neutralize reactive therapeutics and reduce treatment response

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(2015) 10:e0121313

While many use a standard fixed dose, more precise research protocols calculate the dosage based on micrograms per kilogram of body weight (typically 5-10 mcg/kg) for greater accuracy