Subcutaneous administration in normal and metabolically dysregulated mice significantly inhibits NNMT activity in metabolically active tissues (adipose, liver, muscle), increases systemic NAD+ levels, enhances mitochondrial function, and improves energy metabolism
Discussion Significance of the study To our knowledge, this is the most comprehensive network meta-analysis comparing the efficacy of SL, IM, and oral routes of administration of vitamin B12 in patients with vitamin B12 deficiency
Maintaining adequate Vitamin B12 levels is crucial for overall health and well-being
Methylcobalamin serves as a cofactor for methionine synthase, an enzyme critical for DNA synthesis, neurotransmitter production, and homocysteine metabolism
The outcome is balanced performance and better day-to-day endurance