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American Journal of Physiology-Gastrointestinal and Liver Physiology , 279 (1), G7-G11

Along with the extremely addictive nature of nicotine and its intersection with mental health, youth use of nicotine can impair brain development, increase heart rate and blood pressure, and is associated with reproductive health impacts [9, 10, 11] While the health impacts of long-term nicotine exposure (without being paired with combustible tobacco) continues to be studied, it is important to note that acute symptoms of nicotine sickness can occur when consuming high nicotine levels, which include intense vomiting, nausea, headache, shallow breathing, increased heart rate and blood pressure, and dizziness and tremors

They would have a much tougher time trying to buy nicotine patches

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