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One area of ongoing investigation in exogenous hormone use is the differential cancer risks among individuals undergoing gender-affirming hormonal therapy (GAHT) (329)

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Smoking has decreased by both men and women since the mid-1950s, but much more dramatically for men, who cut their rate in half (from about 55% in 1955 to 26% in 2000), than for women, whose rate fell in the single digits (from about 25% in 1955 to 21% in 2000)

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