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In its proposal, the FDA estimated that the federal government would likely see losses of somewhere in the ballpark of $2 billion in federal taxes while states could lose an estimated $3.7 billion

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Toxins metabolized by CYP1A1: The CYP1A1 enzyme is involved in the metabolism of polycyclic aromatic hydrocarbons (PAH) in the intestines, thus playing a role in smoking -related cancers from the activation of the aromatic hydrocarbons