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This suggests that MMP12 up-regulation by ENDS aerosols containing nicotine is mediated by 7nAChR, and thus, MMP12 and 7nAChR signaling are linked

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The key safety considerations include: Respiratory irritation: Any smoke can cause throat and lung irritation, especially with frequent use Combustion byproducts: Burning hemp creates particles that may impact lung function over time Individual sensitivity: People with asthma or respiratory conditions should consult healthcare providers Quality variation: Unregulated products may contain pesticides, molds, or other contaminants Hemp cigarettes represent a harm reduction approach rather than a risk-free option

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