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By supplementing with 5mg of creatine a day, you can raise the amount stored, boosting its effect

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However, the combined effect of multiple BDNF-boosting compounds on total TrkB activation has not been systematically studied, so conservative dosing is advisable

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Patients taking other B-vitamin supplements or multivitamin preparations should inform their prescribing provider, as evaluation for potential additive effects or imbalances may be appropriate