Edwards, Integrated approach to the mechanisms of thyroid toxins: electron transfer, reactive oxygen species, oxidative stress, cell signaling, receptors, and antioxidants
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The ratio of reduced GSH to the disulfide form (GSH/GSSG) within the endoplasmic reticulum ranges from 1:1 to 4:1, whereas the overall cellular GSH/GSSG ratio ranges from 30:1 to 100:1 (Figure 2)
As NADH originates from diverse metabolic pathwaysincluding the tricarboxylic acid (TCA) cycle, -oxidation and amino-acid catabolismcomplex I acts as a metabolic control point that couples cellular metabolic flux to electron transport