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This is consistent with the GRADE approach, in which strong recommendations are sometimes made with low-certainty evidence combined with high certainty of harm or resource implications, and with the value that the task force places on using scarce primary care resources wisely

Reward anticipation then pressures choices, weakening resolve even without deliberate craving language

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The defendants have marketed and sold their lethal product with zeal and with a single-minded focus on their financial success, and without regard for the human tragedy or social costs that success exacted, she wrote