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When receptor proteins on limbic system nerve cells are exposed to high levels of dopamine neurotransmitter molecules for prolonged periods of time, the nerve cells turn down the volume of the signal by lowering the number of receptor proteins on their surfaces

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Nii Addy, PhD, who specializes in the neurobiology of addiction, says nicotine, like any drug, hijacks the reward system in the brain

DNA and protein adducts in human tissues resulting from exposure to tobacco smoke

The absence of tobacco in joints makes them a cleaner way to enjoy marijuana smoke