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One review concluded that vitamin B12 plays a key role in fat metabolism, noting that a deficiency could be linked to increased fat accumulation and obesity ( Another animal study found that severe vitamin B12 deficiency led to a significant increase in body fat percentage and cholesterol levels in pregnant mice ( Whats more, one animal study showed that administering B vitamins to rats fed a high fat diet reduced weight gain and increased levels of several enzymes that influence metabolism, compared with a control group ( However, current evidence is lacking, and additional high quality studies are needed to determine how vitamin B12 may affect metabolism and body fat in humans

We collected data on study characteristics, summarized the quality of evidence, evaluated risk of bias of individual studies using the Newcastle Ottawa Scale, and investigated clinical sources of heterogeneity

First, how can we identify the degree of BBB breakdown and its intricate connection to neurodegenerative diseases within a clinical setting