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When data were below level of detection, the most conservative approach was adopted by taking the middle value of the range between the limit of quantification and detection for analysis (LD + (LQ-LD)/2)

Biol Psychiatry 84:715721 Hong LE, Gu H, Yang Y, Ross TJ, Salmeron BJ, Buchholz B, Thaker GK, Stein EA (2009) Association of nicotine addiction and nicotines actions with separate cingulate cortex functional circuits

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A review of erectile dysfunction studies concluded that men who smoke have a higher risk of developing erectile dysfunction than non-smokers, regardless of age