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Nicotine Alters the Sleep Architecture Healthy sleep follows a structured cycle that includes light sleep, deep sleep, and REM sleep

A 2002 study by the National Institute for Occupational Safety and Health (NIOSH) for example, found that diacetyl a flavoring inhaled by workers at microwave popcorn plants caused severe obstructive lung disease, or popcorn lung. Diacetyl is commonly used in e-cigarettes as well as many other flavorings whose safety in inhaled form is unknown

10.1002/ptr.1653