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Gradually tapering the dose over an additional 46 weeks should successfully lead to termination of therapy

I may have seen it specifically sometime earlier than that

Generally, strengths are categorized into low (3mg to 6mg), medium (12mg), and high (20mg and above)

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(Interestingly, history is repeating itself now with the increasing popularity of e-cigarettes, which produce several vaporized chemicals, have no regulatory oversight, and contain varying amounts of nicotine.) Cigarette smoke is a complex mixture of gases and submicron-size particulate matter [35]