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89 When mitochondrial fusion is suppressed by the down-regulation of OPA1, resulting in elevated ROS levels while an decrease in antioxidant enzyme levels, finally contributing to oxidative stress and cellular damage

Work Package CoDirector, European Medical Information Framework (EMIF)AD Innovative Medicines Initiative (IMI) 4 years Led a multinational team of 30+ scientists and developed the consortiums research strategy

[PubMed: 18094741] (45 year old man developed fatigue and body aches and took 4 g of acetaminophen for 2 days developing jaundice, stupor and coma [bilirubin 11.3 mg/dL, ALT 580 U/L, Alk P 406 U/L, IgM anti-HEV positive]

And we dont do that kind

Switch to a different GLP-1 agonist like semaglutide , which some people tolerate better