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Tobacco or nicotine quickly reaches the brain when it is inhaled or absorbed in the body and binds to nicotinic acetylcholine receptors, according to research published by the National Library of Medicine

it can contain potentially harmful substances, including nicotine, cancer-causing chemicals, heavy metals (such as nickel, tin, and lead), tiny particles that can be inhaled deep into the lungs, volatile organic compounds, and flavorings

Cui said the findings, recently published in the American Journal of PhysiologyRegulatory, Integrative and Comparative Physiology, give further evidence of the harmfulness of smoking