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We think that while it is clear that different endpoints may yield quite different results, the human MOE for cannabis based on the endpoint psychotropic effects can be seen as general validation of the MOE concept, because the resulting values below 1 are expected as the psychotropic effect is the desired endpoint (and hence the psychotropic threshold dose is exceeded by drug users)

Of course, an allergic reaction requires immediate medical attention

SInce most pipe smokers today like to keep a stock or various tobaccos, covering different tastes and styles, it is essential that the smoker properly stores their wares

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Flavoring is fairly self-explanatory