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Research has found that smokers have sperm with a lowered quality as compared to nonsmokers

"Many signals tied into developmental pathways," said the study's lead author Dr Bonnie Joubert, an epidemiologist at the US National Institute of Environmental Health Sciences (NIEHS), noting that changes were seen in genes relating to lung and nervous system development, smoking-related cancers, and birth defects such as cleft lip and cleft palate

Effects of smoking on pegylated interferon alpha 2a and first generation protease inhibitor-based antiviral therapy in naive patients infected with hepatitis C virus genotype 1

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