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For all substances, response options allowed for differentiation between two levels of decrease (slightly less, much less) and increase (slightly more, much more), no change, and non-consumption (abstention)
91-222), which slightly modified the warning statement on cigarette packages, but did not require any warnings in cigarette advertisements
North America leads with 34.6% revenue share in 2025, driven by FDA PMTA-authorized product expansion, mature DTC online retail infrastructure, and strong consumer trust in compliant e-cigarette brands across the United States and Canada
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