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However, as the disease progresses into a chronic phase, the expression of Sema3A gradually increases, potentially inhibiting further neurite outgrowth and contributing to a reduction in cutaneous nerve fiber density (82).Recent evidence highlights that, rather than total nerve fiber density alone, qualitative alterations in specific subsets of sensory fibers such as increased branching, convoluted trajectories, and terminal swellings represent key morphological features of peripheral sensitization (82, 83)

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Epub 2019 Sep 19

Using the MHQ App requires users to have a registered account at Marlboro.com, and the app claims it verifies users are smokers and at least 21 years old