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Cigarette smoking remains the leading cause of preventable death and disease in the United States, accounting for 490,000 premature deaths per year

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Both showed a potential benefit for smoking cessation and high levels of continued e-cigarette use at the end of the intervention, but presented no long-term safety data, which aligns with the findings of our analysis.104 , 105 The patient engagement activities undertaken for this guideline to assess patient preferences included 19 individuals in phase 1 and 8 in phase 2, and were limited in terms of diversity, so may not be generalizable to the broader population

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