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Avoiding risk factors such as smoking, chewing tobacco, heavy alcohol consumption and oral infections may help to prevent oral cavity cancer

The health consequences of using smokeless tobacco: a report of the Advisory Committee to the Surgeon General

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Using comparable rates of exposure of rats to smoke (approximately 20% less than the PM study rats), the BAT scientists report similar deleterious histopathological findings as Project MIX: increased density of goblet cells in respiratory epithelium, increased hyperplasia/degeneration of the nasal cavity, and increased epiglottal metaplasia