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Cytokines found in the sera and skin of morphea patients in increased concentration include IL-4, IL-6, and IL-8.18 These cytokines (especially IL-4) upregulate TGF-, initiating a cascade of events resulting in increased production of collagen and other extracellular matrix components via induction of connective tissue growth factor, platelet-derived growth factor, and matrix metalloproteinases

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Control is effortless with the touch panel and timer settings (2/4/8H)

1h, Supplementary Fig