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Mechanistically, the effects of cannabis smoke may be partially related to an effect on alveolar macrophages

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While heating refill fluids can increase toxicity by formation of carbonyls through decomposition of flavor chemicals or glycerol/propylene glycol 27,28 , the authentic flavor chemicals examined in our study showed toxicity independent of reaction products produced by heat

Additionally, the number of neighborhoods with 3 or more retailers selling these cigars per 100 youth residents decreased from 12 stores to 3, reducing neighborhood-level disparities in retail availability

Take shorter puffs: Aim for three to four second draws rather than long, deep inhales