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We defined nonsmokers as those who had never smoked or smoked less than 100 cigarettes in their lifetime, past smokers as those who had smoked at least 100 cigarettes in their lifetime but had quit smoking at the time of interview, and current smokers as those who had smoked 100 cigarettes in their lifetime and currently still smoke cigarettes at the time of diagnosis

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The toxic components in cigarette smoke have been considered the greatest contributor to serious diseases, and the underlying pathological mechanisms have been widely studied (Smith et al., 2002)

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