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461 However, metformin may interfere with the improvement of some physiological functional parameters, such as whole-body insulin sensitivity and cardiorespiratory fitness, and may have a negative effect on the hypertrophic response in healthy elderly individuals

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In addition, the high expression of NRF2 enhances the expression of downstream SOD1, an important antioxidant enzyme that plays a crucial role in protecting cells from oxidative damage [36]

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