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Study design and population Retrospective observational study of 40 patients referred to hematology for persistent leukocytosis, in whom tobacco use was determined to be the cause after exclusion of infection, inflammatory conditions, and clonal hematologic disorders

The relevance to clinical arrhythmogenesis of these experimental observations (showing the PVs as a favored zone for reentry) has been demonstrated with high-density epicardial mapping in humans (43) (Figure 3DG)

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