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As European encroachments on Native Americans lands and demands on their labor increased, native peoples sought to defend and maintain their political sovereignty, economic prosperity, religious beliefs, and concepts of gender relations through diplomatic negotiations and military resistance Extended contact with Native Americans and Africans fostered a debate among European religious and political leaders about how non-Europeans should be treated, as well as evolving religious, cultural, and racial justifications for the subjugation of Africans and Native Americans

"Betel-quid and Areca-nut Chewing", Betel-quid and Areca-nut Chewing and Some Areca-nut-derived Nitrosamines , International Agency for Research on Cancer, retrieved January 1, 2026 "Bidis: An Overview" (PDF)

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Still, there are few or no significant studies or reliable information in support of this