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Data from the two Phase 3 trials have shown very low rates of side effects, with no serious treatment-related adverse events reported

PMID 24259045

The rate of mental health decline is up to five times faster in smokers than non-smokers due to the clotting and artery damage caused by the use cigarettes

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[103] In 2008, Keaton starred alongside Dax Shepard and Liv Tyler in Vince Di Meglio's dramedy Smother , playing the overbearing mother of an unemployed therapist, who decides to move in with him and his girlfriend after breaking up with her husband (Ken Howard)