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FIGURE 6 5.1 In vitro tests Caudatin has been found to exhibit significant growth inhibition and induces apoptosis in a variety of cancer cell lines, such as hepatocellular carcinoma cell lines (HepG2 and SMMC-7721), breast carcinoma cell line (MCF-7) and lung carcinoma cell line (A549), with IC 50 values ranging from 3.11 to 44.68 mol/L ( 5.2 In vivo tests Studies conducted in animals such as rats and mice showed that caudatin did not cause significant side effects or systemic toxicity at therapeutic doses ( 6 Conclusion This review highlights the therapeutic viability of caudatin from structural optimization, pharmacological mechanism, and clinical implications, suggesting it as a multi-facilitive scaffold for drug discovery

Upon induction of hypoxia, HIF1 is no longer polyubiquitinated and can form a functional heterodimer with HIF1, allowing it to translocate to the nucleus and induce transcription (261)

Biochemistry 35, 1370913715

Leary said

Conclusion Injectable glutathione is marketed as a quick-fix for detoxification and cosmetic enhancement, but lacks strong scientific backing and FDA approval