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Regarding genotoxicity, in vitro work performed by Yu and colleagues using a laryngeal cancer cell line (HN30 and UMSCC10B) exposed to e-cigarette extract showed increased comet tail length and H2A.x (95), indicative of increased DNA damage, and in particular, double-stranded breaks

PMID 12045640.

Major regulations include the WHO FCTC Protocol, the EU Tobacco Products Directive (TPD), and country-specific anti-illicit trade laws requiring track-and-trace systems.

The government has outlined plans to introduce new restrictions which will tighten up how accessible vapes are