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Beyond the well-established roles of histamine, IL-31, and neuropeptides in sensory modulation, purinergic signaling mediated by ATP has recently emerged as a critical complementary pathway in the sensitization of the mast cellneuron axis in AD, with particular attention to the P2X3 receptor

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According to the CDC (Centers for Disease Control and Prevention), cigarette smoke has about 7,000 chemicals, with 69 carcinogens

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