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This is an area where future research will be critically important

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Patients come in after months of physical therapy that stalled, gut symptoms that standard GI workups couldnt explain, or joint pain that responded to nothing

Conversely, administration of the colony stimulating factor-1 receptor (CSF-1R) inhibitor, PLX3397, in a mouse model of stroke eliminated microglia, resulting in increased infarct size, neuronal signaling dysregulation, and cell death, which was reversed markedly by microglial repopulation (Szalay et al., 2016)