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Notably, compared with serum, continuous monitoring in patients with recurrent GBM (n=4) undergoing a specific biochemotherapy regimen (irinotecan, thalidomide and doxycycline) revealed that MMP-9 levels in the cerebrospinal fluid (CSF) significantly and continuously increased over the treatment period (P=0.001), and this elevation preceded magnetic resonance imaging (MRI) detection of tumor progression signs, suggesting that CSF-derived MMP-9 could serve as an early biomarker for GBM recurrence or progression (63)

These include germline mutations in ATM [54] as well as BRCA when poly(ADP-ribose) polymerase inhibition is applied as an adjuvant [55]

Withdrawal symptoms may begin after as little as Withdrawal symptoms may be mild in people who take the drugs for short periods

The upregulation or pharmacological activation of GPX4 helps maintain mitochondrial membrane integrity, prevents mtDNA oxidation and sustains ATP production during oxidative stress (90)

Sep 2023;15(9):e45608