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The major cricitism is that one measure (speed/volume of nicotine delivery) may not capture the multiple factors that allows an artificial device to replicate what the smoker can do to individualize and optimize the pattern of nicll convention al cigaretttes vary little in actual ability for a user to extract nicotine in the needed dose, variation of amount during, deposition, an induced reward and treatment of withdrawal

There was a minimum washout period of 1 week between drug sessions to preclude potential CBD carryover effects following previous research 23, 24

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