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Research shows sulforaphane reduces inflammatory markers (IL-1, IL-6, iNOS) in aged microglia while upregulating Nrf2 target genes

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206 In addition, expression of the mitochondrial isoform of phosphoenolpyruvate carboxykinase, involved in gluconeogenesis from non-carbohydrate carbon substrates such as pyruvate, lactate, glycerol and glucogenic amino acids, was significantly increased, 499 indicating an elevated demand for free glucose through enhancing astrocytic glucose metabolism in GDI1 -null mice

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The balance between the need for NADPH or ribose 5-phosphate determines the direction of the non-oxidative arm (Wamelink et al., 2008)