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In some instances, upon administration (e.g., intratympanic injection) of a conventional otic formulation or composition (e.g., DSP in a buffer), the concentration of a drug in the perilymph of an individual will rise sharply (C max at about 1-2 hours) and then taper off to below C min

Krauth-Siegel RL, Blatterspiel R, Saleh M, Schiltz E, Schirmer RH, Untucht-Grau R (1982)

Always store and handle in amber tubes or under low-light conditions

Their internal operational structure also appears to reflect a traditional vertically integrated manufacturing model