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And the object is to provide a compressible and expansible roll or cylinder composed of an absorbent material which in its compressed form may be applied within a cavity of the body and when so applied may be released from compression and automatically expand The interior of the body may be cored outto afford room for a medical substance, which will saturate the material and eventually reach the surface and be applied to the diseased member

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Previous studies, including our studies, reported that nicotine promotes the chemotaxis and migration of mammalian VSMCs [28, 29]

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Taken together, a significant reduction in carcinogenesis endpoints in vitro and tumor formation in vivo would demonstrate that a cMRTP aerosol is less tumorigenic than cigarette smoke