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Some common side effects include but are not limited to headaches, abnormal sleep disturbances, increased clotting and blood pressure, tachycardia, cancer, joint pain, diarrhea, nausea, and xerostomia

Selby P, Zawertailo L

And that's just the beginning: NGP details

And had the plantations not been generally self-sufficient, the frequently extremely low prevailing tobacco prices would have made the agricultural economy even less profitable

Ingredient addition at the usual level or at levels several times greater than normal does produce some minor changes in the smoke chemistry, but these changes do not result in any adverse biological response as measured in various bioassays to determine mutagenicity, tumorigenicity, etc